Document Type : Original Article
Authors
1
Home Economic Dept., Specific Education Faculty, Port Saied University, Port Saied, Egypt and 2Nutrition
2
Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Cairo, Egypt
Abstract
Avocado is a widely used fruit in many countries for its nutritional and medicinal benefits. This research was conducted to investigate the effect ofavocado (fruits and seeds) supplementation at different levels for 6 weeks on hematology, immune system, liver functions and serum lipid profile in rats. The methanolic extracts of fresh avocado (fruits and seeds) exposed high total phenolic (258.75 and 283.93 mg GAE/100g), flavonoid (2.89 and 3.30 mg CE/100g), antioxidant activity (89.7 and 69.5%) and ascorbic acid (9.35 and 5.22 mg), respectively. Thirty-six adult male albino rats were divided into six groups, the first group, negative control group (-ve) and fed on basal diet only, the other five groups (6 rats each) were subcutaneously injected with a single dose of sheep red blood cell (SRBC) to induced immune suppression, one group of them was served as a positive control group (+ve), while groups 3 and 4 were fed on basal diet supplemented with 5 and 10% of dried avocado fruits, respectively. Groups 5 and 6 were fed on basal diet supplemented with 5 and 10% dried avocado seeds, respectively. The results indicated that, supplementation with avocado (fruits and seeds) at 5 and 10 % to rats diets were significantly increased (P≤0.05) the mean value of IgG and IgM with 123.28, 153.28, 69.73 and 103.28%, respectively for serum IgG and 113.27, 164.60, 57.52 and 70.79%, respectively for serum IgM, compared to the positive control group. Hematological parameters were significantly increased (P≤0.05) for the groups given avocado (fruits and seeds) at different levels. Moreover, liver functions were significantly improved as well as serum albumin, compared to the positive control group, while serum lipid profiles were significantly enhanced. The present study recommended using avocado (fruits and seeds) due to stimulates the immune system of rats with immune deficiency
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