Potential Effect of Garden Cress (Lepidium Sativum) Seeds on Hyperthyroidism in Rats Induced by Lthyroxin

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Department of Home Economics, Faculty of Specific Education, Mansoura University Mansoura, Egypt

Abstract

Abstract: The present work was conducted to estimate the potential influence of garden cress seeds powder (GCSP) at concentrations 5, 10, 15 and 20% on the hyperthyroidism in rats. Thirty six female albino rats, weighing 200 ±10 g. were classified into two main groups. The first main group (6 rats), kept as a negative control group and the second main group (30 rats) were subcutaneous injected by Lthyroxin to induce hyperthyroidism. The last group were classified into 5 sub groups (6 rats per each) as follow: group 2 was left as a positive control group and groups 3, 4, 5 and 6 were fed on basal diet containing 5, 10, 15 and 20% GCSP during the experimental period (60 days). The results indicated that the rats fed on basal diet containing 5, 10, 15 and 20% GCSP showed significant higher in feed intake, body weight gain, FER, TSH, and high density lipoprotein. Whereas showed significantly lower of T3,T4, TG, TC, LDL-c, VLDL-c, AST, ALT, uric acid, creatinine, and urea nitrogen as compared to positive control group. The diet containing 20% GCSP recorded the highest values of all parameters between all tested diets followed by the diet containing 15% of the same powder. Therefore, GCSP at different levels is beneficial to minimize the risk of hyperthyroidism disease. 

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