The relationship between different dietary protein sources and gut microbioma between Parkinson disease animal models

Abstract: Certain gut microbiota species of are involved in neural development and functioning (Gut-brain axis) as well as modulation of brain physiology, mood and behaviors; however their role still unclear. Parkinson disease is the second most common neurodegenerative disorder after Alzheimer's disease that approximately affects seven million people worldwide between mainly the elderly. Nutritional therapy is necessary for such patients to improve malnutrition caused by the decrease of food intake, mal-absorption, accelerated nutrient loss and increase of nutritional requirements. The current study established to investigate the effects of dietary protein supplementation interacted with colonic microbiota in PD animal models. Rats supplemented by 10% extra different dietary protein sources; animal and plant sources. Diets A, B and C representing dried skim milk, soy milk and beans respectively. Additionally, negative and positive control groups of rats were included. Bacterial population on gut, glucose, lipid profile, kidney and liver functions were measured. Collected data showed that consuming different dietary protein sources had induced effective impacts on serum glucose levels, lipid profile (cholesterol, triglyceride…etc.) in addition to kidney and liver functions.  Also, colonic microbiota showed good growth with the colonic probiotic species after additions of the plant dietary protein sources (beans, diet C) comparing to the dietary protein of animal sources. In conclusion, colonic microbiome found to have an interesting role in the disease; however, further more different dietary sources interacted with colonic microbiome composition and activities are needed in addition to different neurodegenerative disorders.