Protective Role of Fig (Ficus carica) Leaves and Ethanolic Extract on Sexual Hormones Deficiency of Postmenopausal Female Rats

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Home Economics Department, Faculty of Specific Education, Mansoura University, Mansoura, Egypt

Abstract

Abstract: Postmenopausal women are exposed to the risk of a big number of health conditions, as osteoporosis and heart disease. In some of these conditions, that risk may be reduced by medication, such as hormone therapy or healthy lifestyle changes. Fortunately, the safe and powerful treatments for postmenopause symptoms are given by the combination between alternative medicine and natural remedies lifestyle changes. This study aims to estimate the effect of Ficus carica (Moraceae) leaves powder and its ethanolic extract on female hormones was investigated in postmenopausal female rats.  Five Sprague Dawley strain female rats at 8-9 weeks young (model of young women) represented in group (1) as negative group (young group) and fed on basal diet (BD). Twenty five Sprague Dawley strain female rats at 24 - 26 months old (model of postmenopausal women) were divided into five groups (5 rats per each) as following. (2) Postmenopausal as positive control. (3) Postmenopausal fed on BD with 5% dried fig leaves powder daily. (4) Postmenopausal fed on BD with 10% dried fig leaves powder daily. (5) Postmenopausal fed on BD with orally 100 mg/kg BW daily fig leaves extract. (6) Postmenopausal fed on BD with orally 150 mg/kg BW daily fig leaves extract for (45 days). The Ficus carica leaves powder and ethanolic extract are showed notable amelioration in all biochemical alteration comparing with postmenopausal (normal control) rats  which including lipid profile, female hormones, calcium levels and antioxidant activity. It could be concluded that administration of Ficus carica powder and ethanolic extract exhibited protective role on sexual hormones deficiency of postmenopausal female rats. 

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