Foeniculum vulgare and its Sprout Extracts as Potential Antiagents for Nephrotoxicity Induced by Cyclosporine in Experimental Rats

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1 Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University,

2 Nutrition and Food Science , Faculty of Home Economics , AL-Azhar University ,

Abstract

The current study was performed to evaluate the protective effect of aqueous extracts of fennel seeds (FS) and fennel seed sprouts (FSS) against renal toxicity induced by Cyclosporine in rats. Thirty-six male albino rats (150±10 g) were used and split into 2 major groups, the first group (6 rats) fed on a basal diet and kept as a negative control, the second group (30 rats) was given orally once daily cyclosporine (30 mg/kg/d) was dissolved in olive oil (20 mg/mL)to induce nephrotoxicity from 14th to 42th day and divided into 5 subgroups. The first subgroup received a normal diet and acted as a positive control group. The second, third, fourth, and fifth categories consumed standard feed with oral dosages of 300 and 600 mg/Kg body weight per day of aqueous FS and FSS extract respectively. Body weight gain (BWG), Feed intake (FI), feed efficiency ratio (FER), and relative kidney , liver weight were computed at the end of the experiment. Assessment of some serum biochemical parameters, kidney tissues were analyzed for antioxidant/oxidant markers, and histopathology of kidneys were assessed. The results revealed that FS and FSS aqueous extracts improved the biological evaluation, kidney, liver functions, Serum electrolytes, antioxidant activity, and histopathology of kidneys compared to the positive group. In conclusion, the administration of aqueous extracts of fennel seeds and fennel seed sprouts have a potent antioxidant and ameliorate in rats Cyclosporine induced nephrotoxicity in rats.

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