Protective Effects of Probiotic Bacteria on Experimental Animals Liver Dysfunction

Document Type : Original Article

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1 كلية التربية النوعية جامعة الاسكندرية قسم الاقتصاد المنزلي

2 قسم التغذية - مستشفيات جامعة المنوفية - شبين الكوم - مصر

Abstract

The present study was designed to investigate the effects of probiotics on the nutritional status and some biochemical parameters of plasma and liver of carbon tetrachloride-induced hepatotoxicity in male albino rats. Twenty five (25) of Sprague-Dawley white male albino rats, each weighing 200±10 g. The rats were divided into five main groups (5 rats each) as follows: group (1) negative or normal group (-Ve): fed on basal diet only, as a control negative. Group (2) positive group (+Ve): fed on basal diet after injection with CCl4, as a control positive. Treated groups: liver disorders group by CCl4, this groups were furtherly divided into three groups as follow: group (3): fed on basal diet plus 10% of sour milk. Group (4): fed on basal diet plus 10% of yogurt. Group (5): fed on basal diet plus 10% of kishk. The results indicated that CCl4 injection was associated with significant increases in the serum levels of total protein and albumin as well as AST and ALT activity as compared with negative control and other diets. As for the TC, TG, LDL-c and VLDL-c; the results found that the group fed on Kishk 10% showed a high significant differences at (P <0.01) compared to the positive control group. This study showed that using yogurt, sour milk, and kishk can protected CCl4– induced hepatotoxicity.

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