Comparison of Antiulcer Activity of (Orang and Purple) Carrot Juice in Rats Gastric

Document Type : Original Article

Authors

1 Specific Education Minia University

2 Home Economics Dept., Faculty of Specific Education, Minia University

3 Minia University, Faculty of Specific Education ,Department of Home Economics

Abstract

Carrot is a nutrient-rich root vegetable grown, consumed globally and contain anti-inflammatory substances as pigments and polyphenol compounds which can be an alternative to prevent peptic ulcers. Non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (INDO) drug to manage acute pain, rheumatoid arthritis and osteoarthritis, but it is cause adverse effects on the gastrointestinal tract, including ulcers and inflammation. Therefore, the current study aimed to investigate and compare the effects of orang and purple carrot juice (Daucus carota L.) on indomethacin-induced gastrointestinal damage in rats. To test these effects of orang carrot juice (OCJ) and purple carrot juice (PCJ) in gastric ulcer; Biochemical and histopathological markers were examination of the stomach tissues in 36 rats were divided in to six groups. The results indicated that INDO caused significant decreases (P < 0.05) in gastric pH and mucin; also, caused increase in total acidity and pepsin compared to control group; While, treatment with OCJ and PCJ showed significant increase in gastric pH and mucin with significant decrease in total acidity and pepsin activity. The ulcerated gastric mucosa of rats by indomethacin had lower GSH (0.613 mg/g) and CAT (0.57 U/g protein) activity, and higher MDA (0.22 nmole/g) content compared to control rats (1.70613 mg/g, 0.81 U/g protein and 0.14 nmole/g) respectively. INDO caused significant increases (P < 0.05) in the value of COX, NF-kB and β -actin for INDO group than control; While, groups treatment with OCJ and PCJ, groups have a near value of control.

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