The effect of Clove and Ginkgo biloba leaf on aluminum chloride-induced Alzheimer's disease in rats.

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faculty of specific education -Ain shams uni.

Abstract

Alzheimer's disease (AD) is a neurological disorder and the leading cause of dementia. The current study aimed to examine whether clove and ginkgo biloba leaf could treat rats with aluminum chloride-induced Alzheimer's disease. AlCl3 (17 mg/kg BW) was administered orally to rats for one month to produce AD. For 30 days, rats were given Ginkgo biloba leaf extract and suspensions (400 mg/kg.BW/day) and clove bud powder extract and suspensions (2mg/kg body wt/day & 800mg/kg body wt/day), as well as combinations of the two. Chemical compositions, minerals, phenolic components, and fatty acid levels were determined for ginkgo and clove. Y-maze test, acetylcholinesterase, MDA, GSH, dopamine, serotonin, nor-epinephrine activity, and brain histological findings were analyzed. The study found that administering dry Ginkgo leaves and clove bud powder extracts or suspensions significantly improved cognitive functions in AD rats, including increased (GSH), and reduced MDA levels in cerebral cortex and hippocampus homogenates. Histological examination also showed improvement. However, utilizing a combination therapy produced better benefits than a single treatment. This study suggests that combining dried ginkgo leaves with clove bud powder can improve AChE levels and reduce oxidative stress in the brain, potentially treating cognitive dysfunction associated with AlCl3-induced Alzheimer's disease.

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