Document Type : Original Article
Authors
1
Department of Food Processing, Faculty of Industrial and Energy Technology, Samannoud Technological University, Egypt
2
Faculty of Home Economics - Menoufia University - Menoufia - Egyptز
3
Faculty of Home Economics, Menoufia University, Menoufia, Egypt
Abstract
The primary objective of this study is to explore the potential impact of incorporating Cantaloupe peels and leaves powder, as well as their combination, into diets in alleviating hyperglycemia-related complications induced by Alloxan in rats with diabetes. A total of forty-eight male albino rats, weighing 150±10 g, were utilized and split into two primary groups. The initial group comprised 6 rats and served as the negative (-ve) control group, being fed the basal diet. The remaining 42 rats were induced with diabetes through alloxan injections and were further divided into seven equal sub groups. The second group continued to be fed the basal diet and served as the positive (+ve) control group. The remaining six groups were provided with the basal diet enriched with 2.5% and 5% of Cantaloupe peels and leaves powder, both separately and in combination. The administration of alloxan to animals resulted in a significant increase (p≤0.05) in serum insulin concentration, marking an 86.45% elevation compared to normal controls. However, supplementing rat diets with 2.5% and 5% of the specified plant components—CPP, CLP, and their Mix—led to reductions in this value by 36.92%, 73.84%, -118.46%, 196.92%, 296.15%, and 453.84%, respectively. Similar patterns were observed in C-peptide, fructose amine, lipid profiles (TC, triglycerides, HDL-c, LDL-c, and VLDL-c), and histopathological changes in the pancreas of diabetic rats induced by varied rates due to the dietary supplementation with the examined plant components.
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