The Neurotherapeutic Properties of Black Raisins and Ginkgo Against Oxidative Stress and Memory Impairment in Alzheimer's Disease Induced by Aluminum Chloride

Document Type : Original Article

Authors

1 Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shebin El-kom, Egypt.

2 nutrition and food science. home economics faculty. menoufia university. shebin el kom. menoufia. Egypt

Abstract

Alzheimer’s disease (AD) is a type of neurodegenerative disease , the pathophysiology of several neurodegenerative disorders involve processes that are influenced by oxidative stress. Aluminum is a strong neurotoxin that can cause oxidative stress, which is linked to neurological conditions including AD. The purpose of the study was to look at the neurotherapeutic properties of dried black raisins(DBR) and ginkgo(Gb) against oxidative stress and spatial memory impairment in AD. 35 mature male Sprague Dawley rats weighing 150 ± 10g divided to 2 primary groups of rats. The first main group, (n=5) , serving as -ve control group that only had a standard diet. The second main group (Alzheimer-rats) (n=30) were given oral administration of AlCl3 (100 mg/Kg /day) for 30 day. Then divided into six subgroups. Subgroup(1), serving as the +ve control was provided with a basal diet for 28 day. Subgroup(2) rivastigmine is given orally to the rats at a dosage of 0.25 mg /day and fed on basal diet. Subgroup(3) is given a basal diet +10% DBR . Subgroup(4) is given a basal diet + 20% DBR. Subgroup(5) were given a basal diet + 10% Gb . Subgroup(6) is given a basal diet + 20% Gb.The results showed inhibition of some neurotransmitter levels as lactate dehydrogenase, Xanthine oxidase , interleukin-6 , acetylcholinesterase , and tumor necrosis factor alpha , amyloid βprotein , acetylcholine and acetylcholinesterase activity. And Improveing at oxidative stress glutathione , superoxide dismutase , Catalase, serotonin , dopamine , and Phosphatidylcholine transfer protein.

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