Potential Ameliorative Effects of Oat (Avena Sativa L.) and its ‎Efficacy Against Lead Toxicity in Experimental Rats

Document Type : Original Article

Authors

1 Fayoum University

2 Helwan university

Abstract

The study aimed to assess the dietary significance and the ameliorative effects of ‎oat (Avena Sativa L.) against lead toxicity in experimental rats during their growth ‎period. The results indicated that rats fed on ‎oats at 10% and 20% of their intake showed a significant decrease in serum lead ‎levels (0.016 mg/dl) and (0.005mg/dl) respectively, comparing to G2. In addition, ‎there were noticeable improvements in iron and hemoglobin levels in rats fed on ‎oats of their diet, the best result was in G4 (341.33mg/dl) and (14.03mg/dl) ‎respectively. Regarding liver enzymes ALT, AST and ALP were significant ‎decreased in G3 and G4 comparing to G2. Improvements in kidney functions ‎were also shown in all examined groups comparing to G2. Furthermore, the ‎antioxidant enzymes SOD and CAT showed a significant improvement in all ‎tested groups comparing to G2. It can be concluded that a significant ‎improvement was evident in the changes induced by exposure to lead acetate in ‎the groups of rats that consumed oats in the diet. Results scientifically proved that ‎oats have significant therapeutic effects against intoxication caused by lead acetate. ‎Oats have potential health benefits as a functional supplement that has a role in ‎liver and kidney protection and enhancing the antioxidant system against lead ‎toxicity. The current study's recommendation is that increasing of oats in the diet ‎may be beneficial against lead toxicity.‎

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