Possible Ameliorative Properties of Tribulus terrestris Extracts Against Liver and Kidney Toxicity Caused by Ivermectin in Rats.

Document Type : Original Article

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Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shebin El-kom, Egypt.

Abstract

The current study sought to determine whether Tribulus terrestris fruit extracts could protect rats from hepato-renal damage brought on by ivermectin.To assess the effectiveness of Tribulus terrestris extracts against liver and renal toxicity as well as related histopathological alterations ,vitamin "C" was employed as a comparison standard medication . Thirty rats were divided into two main groups; the first main group (6 rats) received a basal diet and used as the negative group.The second main group of 24 rats received ivermectin (IVM) (200 mg / kg of body weight ) for 30 days in order to develop hepatic renal toxicity. Four separate groups were created from the second main group: Group 2 received a basal diet and used as the positive control group. Groups 3 and 4 consumed a basal diet in addition to oral Tribulus terrestris (TT) ethanolic and aqueous extracts (200 mg per kg of body weight) , respectively. Group (5) consumed a basal diet along with oral vitamin "C" (200 mg per kilogram of body weight) for 28 days. Phenolic compounds in TT extract were identified using a high-performance gas chromatograph. The outcomes proved that groups of rats administered for 28 days with Tribulus terrestris extracts as well as vitamin "C" at a dose of 200 mg/Kg body weight have shown improvement in feed efficiency ratioو body weight gain, feed intake , function of the kidneys and liver variables , serum and urinary electrolytes (sodium and potassium), some immunological profiles and antioxidant enzymes activity

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