Potential ameliorative effects of Sonchus oleraceus against hypercholesterolemic induced by high-fat diets in albino rats

Document Type : Original Article

Authors

1 Home Economics Dept., Faculty of Specific Education, Minia University

2 Home Economics Department, Faculty of Specific Education, Minia University, Minia, Egypt.

Abstract

This study was conducted to find out the potential effect of Sonchus oleraceus on biological, biochemical, and histological changes of hypercholesterolemic rats induced by high fat diets. Therefore, Thirty-two Adult male albino rats Sprague Dawley strains, weighing 102±1.85 gm were used, and were divided into two groups; the first group (8 rats) fed on basal diet throughout the experimental periods (16 weeks) and served as a negative control group (G1). The second group was fed a high fat diet containing cholesterol, then this group (n=24 rats) was divided into three subgroups (8 rats per each) as follows: The first subgroup continued to be fed on hypercholesterolemic diet (G2), The second subgroup fed on hypercholesterolemic diet supplemented with Sonchus Oleraceus 5 % (G3). The third subgroup fed on hypercholesterolemic diet supplemented with 10% Sonchus oleraceus (G4). The results revealed that hypercholesterolemic diet rat groups showed a significant increase in body weight from positive control (G2). Also increase significantly levels of lipid profile, liver enzymes (AST, ALT and ALP) and cholesterol, except high-density lipoprotein cholesterol (HDL-c) compared to negative control grope (G1). When feeding rats with a high hypercholesterolemic diet containing Sonchus oleraceus occur significant (P ≤ 0.05) decrease in body weight, liver enzymes (AST, ALT and ALP), kidney function and level of lipid profile (TC, TG, T. Lipid and LDL) and increase in the level of HDL. These results were confirmed with histopathological examination of liver, kidney, heart and brain.

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