Study the Potential Protective Effect of Ethanolic Extract of Coriander (Coriandrum sativum) Leaves and Seeds Against Lead Toxicity in Rats

Document Type : Original Article

Authors

1 Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shebin El-kom, Egypt.

2 faculty of home economics-menoufia university

Abstract

Bioactive compounds found in natural sources have the potential to act as oxygen free cleaners or metal chelators, enabling their use as natural antidote for heavy metal toxicity. So, in this research, the ethanolic extract of Coriandrum sativum leaves and seeds was evaluated for its potential effect in reducing the harmful effect of lead in rats. Thirty rats were randomly divided into 6 groups.Group1 set as a negative control group. Group 2 received a daily dose of lead acetate (40 mg/kg body weight orally) for 7 days for induction of oxidative stress then reclassified into 5 groups .Group2was left as a positive control group .Group three and four received an oral dose of coriander leaves extract (100 and 200 mg/ kg), respectively.While the fifth and sixth group received an oral dose of coriander seeds extract (100and200mg/kg), respectively. The content of coriander leaf and seed extracts of phenolic and flavonoid substances was estimated.Also, the effect of these treatments on lead concentration in serum,liver and brain, kidney and liver function markers,lipid profile, oxidative stress markers, glucose level , and histopathological changes in liver and brain was evaluated .The results showed an increase in indicators of liver and kidney function ,lipid profile, glucose level and in the signs of oxidative stress in rats treated with lead acetate,while the effect was mitigated by leaf and seed coriander extract.Also,extract improved the tissue structure of the liver and brain.

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