Date Seeds (Phonix dactylifera L.) extract mitigates the hepato-renal toxicities induced by monosodium glutamate in male albino mice.

Document Type : Original Article

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Home economics, faculty of specific education,Tanta university

Abstract

Monosodium glutamate (MSG) is a common food additive, however, food containing MSG causes several health problems. Natural products reduced the adverse effects and may permit to safely administer of MSG as food additive. This study aimed to evaluate the protective effect of Phoenix dactylifera seeds extract (PDSE) against MSG toxicity in albino mice. Gas-chromatography mass spectrometry (GC/MS) analysis and phytochemical analysis were assessed in PDSE. Thirty-six male CD-1 mice were divided into three groups (n=12): The first group (Gp 1) was served as a negative control. Gp2 had administered with MSG (60 mg/kg) orally for 2 months. Gp3 had administered with MSG as in Gp2 then administered with PDSE (100 mg/kg) daily for two months. Mice were sacrificed after the blood was drawn for haematological and biochemical examination, and the liver and kidney tissues were harvested for histopathological investigations. The phytochemical analysis showed that PDSE had potent antioxidant activity. The results showed that the administration of MSG-treated mice with PDSE led to significant improvement in the hematological changes, liver transaminases, urea, and creatinine levels, also resulted in restoration of the antioxidants/oxidants hemostasis, and histopathological alterations. Collectively, the study showed the potential ameliorative effect of PDSE against the hepatorenal toxicities that induced by MSG.

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