Antioxidant Effects of Soursop Extract and Nigella ‎Sativa Seeds Against Oxidative Stress Induced By Mono ‎Sodium Glutamate in Male Rats

This study was conducted to determine the effect of Soursop extract and ‎Nigella sativa seeds against oxidative stress induced by mono sodium glutamate ‎in rats. The obtained results showed that (MSG) treated group recorded ‎significant elevation in body weight . The result demonstrated that (MSG ‎group) showed significant increase in the serum levels of total cholesterol, ‎triglyceride, ALP, ALT, AST, total bilirubin and significantly reduction in the ‎levels of total protein and albumin compared to control group. While, the ‎treated groups (MSG + SE) and (MSG + NSS) showed improvement in the ‎levels of these biochemical parameters. Monosodium glutamate increased the ‎appearance signs of oxidative stress such as significant increase in MDA levels ‎and significant decrease in SOD, CAT, GST and GSH levels in (MSG group) ‎compared to control group. On the contrary, the treated groups (MSG + SE) ‎and (MSG + NSS) had the ability to normalized the oxidant status of the liver ‎cells. Pathological histological lesions of the liver in (MSG) group were also ‎observed. It is noticeable that there was a clear improvement in the histological ‎structure of the liver of rats in (MSG + SE) and (MSG + NSS). In conclusion, ‎the results of the study indicated that Soursop extract and Nigella sativa seeds ‎had anti-inflammatory and antioxidant properties, which are potential ‎mechanisms to enhance liver dysfunction and protect the liver cells. Therefore, ‎Soursop extract and Nigella sativa seeds can be considered among the plants ‎that have a role in protecting the liver. ‎