Comparative Study among, Olive , Avocado, and Mango leaves in Diabetic Rats

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Nutrition and Food Science Dept. Faculty of Home Economics AL- Azhar University

Abstract

ABSTRACT
This study was conducted to acquaintance the effectiveness of olive , avocado and mango leaves on experimental rats suffering from diabetes mellitus. Forty-five male albino rats weighing 190 ±10 g were used. After the adaptation period , rats were divided randomly into two main groups; the negative control group (C-) 5 normal rats fed on a basal diet and the second group (n=40) were injected subcutaneously with Streptozotocin (STZ) at (45 mg/kg b.wt ) dissolved in 0.01 M citrate buffer (PH 4.5).Then rats were divided into eight groups (each group consisted of 5 rats group of them fed on basal diet and left as positive control group (+) ,the other groups treated with, Metformin at dose 200mg/kg b.wt , olive leaves powder 3%, Mango leaves powder 3%, Avocado leaves powder 3%, olive leaves aqueous extract 20% ,mango leaves aqueous extract 20% and Avocado leaves aqueous extract 20%. Results showed that (STZ) injection led to a significant elevation in the relative weights of the liver, kidney and pancreas ,serum levels of glucose , triglyceride ,total cholesterol, LDL-C, liver enzymes, creatinine and urea nitrogen. Conversely , feed intake , body weight and HDL-c were significantly reduced. In general , it has been shown that the leaves of olive , mango and avocado as a powder or as aqueous extract have antioxidant and hypoglycemic effects ,so they alleviated the studied disorder were resulting from hyperglycemia.

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