Study the effect of combining curcumin and black pepper in different proportions on obese diabetic rats

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faculty of Arts and Science- Northern Border University - Saudi Arabia

Abstract

This study aims to study the effect of the combination of curcumin (CUR) and black pepper on obese rats with diabetes. Thirty-six male albino rats weighing 150 ± 10 g were used and divided into 6 groups (each group 6 rats) and the duration of the experiment was 4 weeks. The first group, the control group, was fed the basic diet. The main group (30 rats) fed for 2 weeks on a high fat diet (HFD) to induce obesity and injected with alloxan 150 g/kg body weight to induce diabetes, were divided into 5 groups. The second group was fed the basal diet, the third group was fed the main ration and 2.5% CUR, the fourth group was fed the basal ration and 5% CUR, the fifth group was fed the basal diet, 2.5% CUR and 1.5% black pepper. The sixth group was fed basal diet, 5% CUR and 5% black pepper. The results showed a decrease in the weights of the groups fed curcumin and black pepper. The blood glucose level in the (G5) group fed 2.5% decreased with 1.5% black pepper (131 ± 9.89) compared to the positive control group (255.5 ± 12.02) and the total cholesterol level in the fed rat group was decreased by 5%. CUR with 5% black pepper (171 ± 9.89) compared to the positive control group (285.5 ± 7.77), so the study recommended combining CUR with black pepper in moderate proportions to get good resul

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