Biological, Biochemical and Histopathological Alterations by Lemon Tree Leaves and Lemon Fruit Peels in Therapeutic Feeding of Diabetic Rats

Document Type : Original Article

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Department of Family Education Faculty of Education Umm AL-Qura University

Abstract

This investigation aimed to evaluate the effect of lemon tree leaves, lemon fruit peel and mixture of both on male diabetic rats. Thirty (30) adult male Sprague Dawley rats were divided into five groups. Group (1): Normal rats fed on basal diet as control negative (C-), Group (2): Control positive (C+) (untreated group). Group (3): Diabetic rats fed on basal diet and lemon tree leaves (4%). Group (4): Diabetic rats fed on basal diet and lemon fruit peel (4%). Group (5): Diabetic rats fed on basal diet and mixture of both plants (4%). At the end of experiment, after 28 days of feeding, all serum samples were analyzed for biological, biochemical and histopathological parameters. Injection with alloxan caused a significant decreases in the levels of HDL, BWG, FI & FER while significant increases recorded in TC, TG, VLDL, LDL, U.A, Creatinine, Urea, GOT, GPT, ALP & Glucose for diabetic rats treated with various experimental diets, the results showed the improvement in all previous parameters. The best diet was that of the basal diet and lemon fruit peel (4%). Nevertheless the lemon tree peel diets improved also parameters of diabetic rats, although at less extent.

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