Study the potential effect of ( fenugreek and flaxseed (seeds on acute renal failure in rats

Document Type : Original Article

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Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Abstract

Acute kidney injury is increasingly common around the world; so that the present study was carried out to investigate the potential effect of fenugreek and flaxseed seeds on acute renal failure in rats. Thirty-six male albino rats weighing 140 ± 10 g were used in this study and divided into two main groups, the first main group ( 6 rats ) kept as a negative control group(v -) received a basal diet throughout the experiment period ( four weeks ), while the second main group (30 rats) were injected by glycerol to induce acute renal failure and divided into five subgroups, the first was the (v +) control group, the second and third given a basal diet supplemented with fenugreek (5%) and (10 %),respectively. The four and five given a basal diet supplemented with flaxseed (5%) and (10%), respectively for four weeks. The chemical composition, total phenolic and total flavonoids contents for both plants were done. At the end of the experiment, biological data were calculated; blood samples were taken to biochemical analysis. In addition, a histopathological examination for the kidney was done.

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