Antidiabetic‏ ‏Effect of Defatted (Linum usitatissimum L.)‎‏ ‏on Hepatic Lipid ‎Metabolizing and Lipid-Regulating Enzymes of Alloxan-Induced Diabetic ‎Rats.‎

Document Type : Original Article

Authors

1 Home economics/ helwan university

2 Home Economics, Helwan University ‎

3 Faculty of Specific Education, Fayoum University‎

Abstract

35 male albino rats weighting 180 ±5 g divided into 5 groups, each of ‎‎7 rats for 30 days. The first group fed on basal diet, served as a normal control group. Twenty eight ‎rats were injected by alloxan with a single intravenously (40 mg/kg b.w) to induce diabetes and ‎randomly classified to 4 groups, diabetic (untreated), the other three groups treated with oral ‎administration of flaxseed extract (FE) at a dose of 150 ml/kg BW and (10% and 20%) flaxseed ‎powder (FP), FE followed by FP groups showed significant improving in ‎diet consumption parameters compared to diabetic control, flaxseed administration caused a ‎significant reduction in plasma glucose‏ ‏and plasma insulin. Furthermore, significant amelioration in ‎tissue liver lipid peroxidation (MDA) were conducted in treated-diabetic rats however, SOD, GPx ‎and GSH antioxidant enzymes increased significantly compared to negative control group. High ‎flavonoid contents with total phenols tend to make significantly mended the hepatic lipid-regulating ‎enzymes such as glucose 6-phosphate dehydrogenase (G6PD), β-oxidation activity and fatty acid ‎synthase (FAS) near normal levels especially PE group followed by FP 20% then FP 10% compared ‎to non-treated diabetic control.In conclusion, Oxidative damage associated with diabetes was ‎ameliorated with treatment with flaxseed extract and powder. The attenuate effects are mainly ‎attributed to antioxidant properties and the presence of bioactive and nutraceutical compounds ‎especially flavonoid contents in high amounts. ‎

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