Hepatoprotective Activities of Some Herbs with or without Honey against Ccl4 Induced Hepatotoxicity in Female Albino Rats

Author

Nutrition and food science - Faculty of Home Economic - AL-Azhar university - Tanta - Egypt

Abstract

A total number of 50 Sprague Dawley strain female albino rats (200±10g each) were used in the present study, to evaluate the effect of phytogenic diet (Gentiana, Glycyrrhizae, Ginseng and Rheum) at 9% levels on the body weight gain (BWG), liver enzymes activities (ALT and AST), serum protein fractions (TP, ALB, GLB and ALB/GLB ratio), lipids profile (TC, TG, VLDL-c, LDL-c and HDL-c) and AI. Rats divided into 10 groups (5 rats each) including control negative (–Ve) fed on basal diet only, control positive (+Ve) fed on basal diet and injected with CCl4, as well as 4 groups consumed a diet containing 9% of herbs without honey and other 4 groups consumed their diets containing 4.5% of herbs powder plus 4.5% of honey. Microscopic evaluations of the liver revealed CCl4-induced lesions and related toxic manifestations that were minimal in the liver of rats pretreated with powders at the dose of 9%/ kg of body weight. The results revealed that all herbs improved the tested parameters, especially that of the Rheum diet. In all diets treatments honey alleviated more the hepatopathy in CCl4 injected rats.

Keywords

Main Subjects

Files

Share

How to cite

Statistics