Potential Ameliorative Effects of Spirulina Using Multiple Biomarkers Toward Lead Acetate Toxicity in Albino Rats

Document Type : Original Article

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Dept. of Home Economics, Faculty of Specific Education, Menoufia University, Egypt.

Abstract

This study was carried out to investigate the potential ameliorative effects of spirulina toward lead acetate toxicity in albino rats. Thirty growing male albinos were divided into two main groups. The first main group was the negative group (6) rats, the second main group (24) rats was exposed to lead acetate (1.5g/L) and divided into four groups. The second was positive group fed basal diet, The third, fourth, and fifth groups fed basal diet containing (1.5%,3%,6%) spirulina, respectively for 30 days. Determined The body weight gain, feed intake and feed efficiency, At the end of the experimental period, Blood samples were collected for serum separation to determine the biochemical parameters. the best result found in group fed basal diet containing (6%) spirulina improved daily feed intake, body weight gain, feed efficiency ratio. Moreover, lead concentration was recorded the significant decreased in liver and brain also, it was improved the concentration levels of iron, copper and liver enzymes in serum of intoxicated rats, compared with positive group. The histopathology results were agreed with the results of serum parameters. These results recommend using spirulina as a safe and effective food supplement as well as reducing lead acetate toxicity.

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