Effect of Sonchus Oleraceus and Malva Parviflora Leaves on Acute Liver Diseases in Rats fed on A High-Fat Diet

Document Type : Original Article

Authors

1 Home economics Dept, women's college, ainshams university.

2 Biochemistry and Nutrition, Home Economics Dept., Women's College, Ain Shams University

3 Nutrition and Food Science Dept. Faculty of Home Economics, Helwan University

Abstract

The present work was carried out to investigate the effect of Sonchus oleraceus (SO) and Malva parviflora (MP) leaves on acute liver diseases in rats fed on a high-fat diet. Forty-five adult male Albino rats of Sprague-Dawley strain were used and divided into three main groups as follows: The first main group was fed on a basal diet "BD", as a control negative group (-ve). The second main group was fed on a high-fat diet "HFD", as a control positive group (+ve1). The third main group was injected with a single dose of CCL4 in paraffin oil (50% v/v 4ml/kg) subcutaneous injection to induce acute damage in the liver. Then the rats were divided into 7 groups as a following: Group (1): was fed on the high-fat diet, as a control positive group (+ve2) Groups (2 and 3): were fed on a high-fat diet containing 2% and 4% SO, respectively. Groups (4 and 5): were fed on a high-fat diet containing 2% and 4% MP, respectively. Groups (6 and 7): were fed on a high-fat diet containing (1% SO and 1% MP) and (2% SO and 2% MP), respectively. The results revealed that total lipids and liver enzymes are increased except high-density lipoprotein cholesterol (HDL-c) and protein in rats fed on HFD (control +ve 1) and (control +ve2) compared to the negative control group. Treating acute liver disease rats which were fed on a high-fat diet with SO and MP leaves led to a noticeable improvement in these parameters.

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