Effect of Sonchus Oleraceus and Malva Parviflora Leaves on Acute Liver Diseases in Rats Fed on Normal Diet

Document Type : Original Article

Authors

1 Home economics Dept, women's college, ainshams university.

2 Nutrition and Food Science Dept. Faculty of Home Economics, Helwan University

3 Biochemistry and Nutrition, Home Economics Dept., Women's College, Ain Shams University

Abstract

The present work was carried out to investigate the effect of Sonchus oleraceus (SO) and Malva parviflora (MP) leaves on acute liver diseases in rats fed on a normal diet. Forty adult male Albino rats of Sprague-Dawley strain weighing approximately (150 ± 10 g) were used (for four weeks) and divided into two main groups as follows: The first main group (5 rats) was fed on a basal diet "BD", as a control negative group (-ve). The second main group (35 rats) was injected with a single dose of CCL4 in paraffin oil (50% v/v 4ml/kg) subcutaneous injection to induce acute damage in the liver. Then the rats were divided into 7 groups as a following: group (1): was fed on a basal diet as a control positive group. Groups (2 and 3): were fed on a basal diet containing 2% and 4% SO, respectively. Groups (4 and 5): were fed on a basal diet containing 2% and 4% MP, respectively. Groups (6 and 7): were fed on a basal diet containing (1% SO and 1% MP) and (2% SO and 2% MP), respectively. The results revealed that total lipids and liver enzymes are increased except high-density lipoprotein cholesterol (HDL-c) and protein in acute liver disease rats fed on a basal diet compared to the negative control group. Treating acute liver disease rats which were fed on a normal diet with SO and MP leaves led to a noticeable improvement in these parameters.

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