Effect of Mushroom /Oat and their mixtures as Functional Food on Lipid Profile, Liver and Kidney Functions of Obese Rats

Document Type : Original Article

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Home Economics Department, Faculty of Specific Education, Alexandria University, Alexandria, Egypt

Abstract

The present investigation aimed to evaluate the effect of mushroom /oat and their mixtures on lipid profile, liver and kidney functions of obese rats. Forty eight male albino rats were used for the experiments, divided into two main groups, first group (n=6 rats) fed on basal diet as a Control (group-ve). Second group (n=42 rats) received high fat diet (HFD) for 8 weeks to induce obesity in rats then divided into (7) subgroups (treatments) each (n=6 rats). Eight weeks later, body weight gain, feed intake and feed efficiency ratio were estimated. Blood samples were collected from treatments to estimate lipid profile, liver enzymes, kidney function and of glucose level. Results showed that, feeding rats on (HFD) led to significant increase in serum cholesterol, triglycerides, LDL-c, and decreased HDL-c. Mushroom plus oat (20+40%) treatment improved the lipid profile compared with other treatments. Moreover, mushroom plus oat (20+40%) reduced the activity of liver enzymes (ALP, ALT, AST and LDH, 280.0 IU/L, 36.7, 50.5 U/ml and 28.4 U/L, respectively to the level close to the non-obese rats. The HFD rats showed the highest level of liver enzymes. Histological study of liver tissues supported the results. Mixtures of mushroom plus oat increased albumin (3.5 g/dl) close to non-obese and HFD rats showed the lowest level of albumin (2.5 g/dl).

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