The potential protective effect of alcoholic extracts of some herbs on hepatotoxicity induced by paracetamol in experimental rats

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AL-azhar University

Abstract

There are many plants which are used as herbs or spices by many people such as Laurus nobilis and Elettaria cardamomum. The present study was carried out to investigate the protective effect of alcoholic extract of Laurus nobilis and Elettaria cardamomum (100 and 200 mg/kg body wt.) on hepatotoxicity induced by paracetamol (400 mg/kg body wt.) in experimental rats. Thirty healthy adult male albino rats weighing (150±10 g.) were used and divided into 6 equal groups, one was kept as a negative control, Group (2): was fed on basal diet as a positive control group, All groups were fed on basal diet + orally doses of herbs as the following: (3, 4) Laurus nobilis100and 200 mg/ Kg b.w.; (5, 6) Elettaria cardamomumum100 and 200 mg/ Kg b.w. Once a day for twenty- eight days on twenty -one day, during the administration of the respective treatments, all animals of groups 2, 3, 4, 5 and 6were administered with paracetamol 400 mg/kg orally for week. At the end of experiment, biological evaluation were calculated. Liver enzymes, bilirubin, proteins and lipid profile were determined in serum. In liver tissue (GPX, SOD, CAT, MDA and α –TNF) were determined. Livers of rats were histopathologically examined. The results showed that alcoholic extract of Laurus nobilis and Elettaria cardamomum improved biological evaluation, liver functions, and antioxidant enzymes compared with positive control groups. It could be concluded that take Laurus nobilis and Elettaria cardamomum have markedly protected against the harmful effects of paracetamol on liver.

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