POTENTIALS PROTECTIVE EFFECT OF RUTA GRAVEOLENS AS ANTIOXIDANT ON CISPLATIN INDUCED TESTICULAR DAMAGE IN ALBINO RATS

Document Type : Original Article

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Department of Home Economics, Faculty of Specific Education, Ain Shams University, Cairo, Egypt

Abstract

The present study was established to investigate that Ruta graveolens' ability to alleviate cisplatin-induced testicular dysfunction in albino rats. Thirty rats were randomly divided into six groups (A–F) of 5 rats each: Group A which attended as control (-) received water; Group B was intraperitoneally (i.p) injected 10 mg kg-1 bw. cisplatin on 6 weeks as control (+). Groups C and D were assumed 50 and 100 mg of R. graveolens via oral administration, respectively, for 6 weeks and then exposed to i.p administration of 10 mg kg-1bw cisplatin on the 6st week ; Groups E and F received 10 mg kg-1 bw of cisplatin intraperitoneally and then recieved 50 and 100 mg kg-1 bw of R. graveolens for 6 weeks orally. Cisplatin-exposed Group B rats had decreased sperm characteristics and higher sperm morphological abnormalities, as well as altered histological architecture of seminiferous tubules and lower glutathione (GSH) levels in the testes. These parameters in R. graveolens alone treated Groups C and D were not markedly different compared with negative control group ;such as sperm count recorded 102.54±3.91 compared with 146.25±3.12 in the control (-) and 56.41±4.10 in the control (+). The rats with the combined treatment in Groups E and F showed significantly improved sperm parameters, testicular histology architecture and antioxidant enzymatic activities. Conclusively, R. graveolens has protective potential against cisplatin damage

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