Potential protective effects of barley and wheat grains on cardiovascular damage induced by tramadol

The present study was conducted to evaluate the potential protective effects of barley and wheat grasses against tramadol induced cardiovascular damage, biochemical changes and oxidative stress in adult male albino rats. Thirty six male albino rats (150±10 g) were divided into two main groups, the first main group was fed on basal diet and kept as normal control. The second main group was fed on basal diet and administrated tramadol (30mg/kg/day) orally for 30 days to induced cardiovascular damage and oxidative stress in male rats. The rats in the second main group (30 rats) were divided into five subgroups (each group consisted of 6 rats). Subgroup1; received tramadol and kept as tramadol group, subgroup2; received tramadol + barley grass (250mg/kg/day), subgroup3; received tramadol + barley grass (500mg/kg/day), subgroup4; received tramadol + wheat grass (250mg/kg/day) and subgroup5; received tramadol + wheat grass (500mg/kg/day) orally for 30 days. Biological evaluation was carried. Relative liver, kidney and heart weight were calculated. Serum was separated from the blood and assessed lipid profile and serum antioxidant markers at the end of the experiment. Results: indicated that lipid profile and serum antioxidant markers were restored significantly in barley and wheat groups at high doses (500mg/kg/day) as compared to the positive control group.