Anti-obesity and Hypolipidemic Effects of GymnemaSyylvestre Leaves on Rats Fed on High Fat Diet

Khateib, Basma Ramadan Mohammed; Abdel Rahman, Abeer Nazeih Abdel Rahman

doi:10.21608/jedu.2020.48434.1113

Anti-obesity and Hypolipidemic Effects of GymnemaSyylvestre Leaves on Rats Fed on High Fat Diet

Authors

Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shebin El-kom, Egypt.

10.21608/jedu.2020.48434.1113

Abstract

This work aimed to study the effects of high fat diet enriched with GymnemaSyylvestre leaves (GSL) on obese rats. Thirty (30) male albino rats weighting 150-160g used in this study and assigned to 5 groups. The negative control group received basal diet throughout the experimental period. However, the experimental groups including 24 rats were feed on specific high fat diet (HFD) for 21 days to induced by obesity and hyperlipidemic rats. Rats fed on high fat- diets treated with GSL at (2,4 and 6%) indicated significantly decrease (p≤ 0.05) in feed intake (F.I), body weight gain (BWG), and feed efficiency ratio (FER) at (p≤ 0.05) comparing with control positive . in the same time the positive control group significantly increased in FI, BWG and FER compared to the negative control group.Also, tested leaves showed a significant decreases (p≤ 0.05) in mean value of liptin Hormone, TSH , T.C, T.G, LDL,VLDL and AI comparing with control positive group. On the other hand there were a significant increases (p≤ 0.05) in means values of T3,T4 and HDL of obese rats treated with GSL.Inconclusion,GSLcould be recommended in our daily drinks and diets in a moderate amount (5-10 g).

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