Potential Effect of Olive Leaves Powder and its Extract on Streptozotocin-Induced Diabetic Rats

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Home Economics Department, Nutrition and Food Science, Faculty of Specific Education, Assiut University

Abstract

The present study aimed to evaluate the effect of olive (Olea europaea) leaves powder and its extract on streptozotocin (STZ)-induced diabetic male rats. The experimental rats were divided into six groups; each group contained 6 rats. Rats of the first group served as normal control. Rats of the second group were diabetic control (STZ at a dose of 45 mg/kg bw.) and served as positive control. The 3, 4, 5 and 6 groups were diabetic rats, treated with olive leaves powder (OLP) and extract (OLE) at low and high doses 2.5 % & 5% and 1 & 3 g/kg; respectively. Effects of olive leave treatment on glucose, plasma parameters, liver, kidney functions and blood picture markers were determined. Also, some active compounds in olive leaves were determined using HPLC techniques. The results showed that the olive leaves ethanolic extract (OLE) of variety exhibited at termination, a significant reduction in blood glucose. The OLE tended to reduce plasma total proteins, cholesterol, triglycerides levels, liver functions (ALT, AST & ALP), kidney functions (urea, uric acid & creatinine) and blood picture toward the normal levels. It could be concluded that, the OLE showed an anti-hyperglycemic activity on STZ-diabetic rats, minimized the adverse effect of oxidative response, protective activity and improves changes associated with diabetes probably due to containment of many potentially bioactive compounds.

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