The role of Green Tea Extract and Vitamin C on malathion-induced testicular oxidative damage in rats

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Nutrition and Food Science , Faculty of Home Economics , AL-Azhar University , Tanta , Egypt

Abstract

Abstract: Malathion is one of organophosphate pesticides that is widely used in agriculture to control insects. This study investigated the role of green tea extract and Vitamin C on malathion-induced testicular oxidative damage in rats. Forty eight adult male rats were divided into 2 main groups. The first group (6 rats) considered as a negative control. The second group (42 rats) administered with Malathion (150 mg/kg body weight) in saline solution to induce testicular oxidative damage. The second group were divided into seven subgroups as a following : control group (+ve),two groups treated with vitamin C (100 and 200mg/ Kg B.W.) and groups treated with alcohol or aqueous green tea extract (150 and 300 mg/ Kg BW). After 28 days, all groups were anesthetized then sperm parameters were measured. Results showed that treated groups were associated with significant increase in sperm motility (%), Progressive motility (%), Normal form, total sperm count (%), (LH) ,GPX, SOD and CAT. In contrast, (FSH) and level of MDA. Malathion-induced lipid peroxidation and oxidative stress in the testis of rats. It seems that antioxidant capabilities ascorbic acid and green tea extract improved malathion-induced poisonous changes.

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