THE PROTECTIVE EFFECT OF CURCUMA AND ROSEMARY ON KIDNEY FUNCTION AND IMMUNE SYSTEM AGAINST HYPERURICEMIA IN RATS

Document Type : Original Article

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Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Abstract

Hyperuricemia is the major and primary risk factor of symptomatic gout . So that; this study was conducted to evaluate the protective effect of curcuma and rosemary powders on kidney function and immune system against hyperuricemia in rats. Thirty male albino rats weighing 130 ± 20 g used in this study and divided into equal six groups ( 5 rats each),the first kept as negative control group (v -) control received basal diet throughout the experiment period, while second was the (v +) control group which fed on basal diet for four weeks followed by feeding on basal diet contains 2.5% uric acid and 5% oxonic acid for seven days to induce hyperuricemia, while the four others groups given diets supplemented with curcuma (1% , 2 %) , rosemary (1 %, 2%) for four weeks followed by feeding on basal diet contains 2.5% uric acid and 5% oxonic acid for seven days . At the end of the experimental period (35 days), the feed intake , body weight gain % , feed efficiency ratio and relative kidneys weight were calculated . Serum creatinine, urea , uric acid , albumin, globulin and total protein were determined. Antioxidant enzymes level in kidney tissues . Also, serum immunoglobulins and Interleukin -6 (IL6) in kidney tissues were estimated . The obtained results concluded that using curcuma and rosemary improved all above biological and biochemical parameters. The best results found by using high doses ( 2%) of curcuma and rosemary .

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