Total Phenolic Contents and Antioxidant Properties of Pulp and Skin of Prickly Pear (Opuntia ficus indica) Fruits: Application on Juice and Jam.
Areeg S
ALy
specific education minia university
author
text
article
2019
ara
he nutritional and health-promoting properties of prickly pear fruit has attracted attention and can may contribute to their increased consumption in the future being rich in bioactive compounds (polyphenols and ascorbic acid). Skin considers the major by-product of the fruit. The main objective of the study was to evaluate the bioactive compounds content, antioxidant activity and sensory quality of prickly pear (pulp, skin and whole fruit) juice and jam. Proximate composition, pH, acidity, total phenols, total flavonoids, antioxidant activity using (DPPH) and sensory evaluation of pulp, skin, whole fruit juice and jam were evaluated. The data revealed that the moisture content ranged from 90.01% ±0.13 to 90.98% ±0.18 for prickly pear skin juice and pulp juice, respectively. Prickly pear skin juice and jam had the highest values of ash 1.347 ±0.02 and 1.00 ±0.03, respectively. Total soluble solid of juice and jam ranged from 8.50% to 8.90% and 68.00% to 67.5% for juice and jam, respectively. The pH values of juice (5.68 – 5.78) were higher than that of jam (4.05 -4.34). Prickly pear skin juice and jam significantly (P≤ 0.05) had the highest values of total flavonoids and total phenols which recorded (379.67 ±9.5 and 204.03 ±5.10 mg/100g) and (152.08 ±5.93 and 151.33 ±1.70 mg/100g), respectively and subsequently high significantly (P≤0.05) values of antioxidant activity using DPPH. Jam processed from skin and whole fruit significantly (P≤ 0.05) had the highest sensory scores. In conclusion, prickly pear pulp, skin and whole fruit juice can be used successful for producing jam content bioactive compounds and antioxidant activity with acceptable sensory characteristics.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
1
17
https://jedu.journals.ekb.eg/article_73380_8e009a6ed1bc206770195ce6fea04f2e.pdf
dx.doi.org/10.21608/jedu.2019.73380
Bioactive compounds and potential antioxidant activities of fruits by-products in Egypt
Khadega M
Sayer
specific education minia university
author
text
article
2019
ara
he present study was aimed for examine the bioactive compounds and antioxidant potential of three fruits by-products (banana peels (BPP), pomegranate (PGPP) and prickly pear PPP) in Egypt. The total dietary fiber content for all fruit by - products PGPP – PPP - BPP was ranged 26.06 - 34.76 g.100g-1, total phenolics was 516 -1267 mg GAE.100 g-1 and total carotenoids were 146.25- 219.11 mg.100g-1. The BPP recorded the highest content of total dietary fiber followed by PPP, mixture and PGPP respectively while PPP the highest in carotenoids and PGPP registered high content in Total phenolic. The fruits by-product PGPP- PPP- BPP extracts indicated that large differences in antioxidant activity (AA, %) was ranged 74.96 - 89.16 %. PGPP showed strong antioxidant activity followed by mixture, BPP and PPP respectively. The results showed that BPP recorded high content of protein, crude fiber and ash 3.64, 28.43 and 3.42 respectively While PGPP recorded high level of Moisture 10.76 and PPP have the highest content of Carbohydrates73.87. In conclusion, result of the current study disclosed that fruits by-products (PGPP-PPP- BPP) can be useful sources of valuable bioactive compounds and antioxidants expand their main uses in nutritional, curative applications and many health benefits.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
19
38
https://jedu.journals.ekb.eg/article_73299_5f3f44fbb8651528fcebb16d3d337189.pdf
dx.doi.org/10.21608/jedu.2019.73299
A Comparative Study on Nutritional Value of Quail and Chicken Eggs
Mostafa A
Ali
specific education minia university
author
text
article
2019
ara
he current study was conducted to compare between nutritional quality of quail and chicken eggs. Proximate chemical analysis, minerals, vitamins, fatty acids and amino acid content of quail and chicken eggs were determined. Results showed that the percent of protein, fats, ash of quail eggs was higher than that of chicken egg. There was no significant difference at P<0.05 between cholesterol content of quail and chicken eggs which was 12.26 and 12.48 mg/g, respectively. Quail eggs scored higher contents in Fe, Cu, Mg and P, while chicken eggs were higher in Ca, Zn, Na and K. The predominant fatty acids in quail and chicken eggs were oleic, palmitic and linoleic acid which were 42.54 and 40.65, 27.53 and 26.96; 16.61 and 16.33%, respectively. The essential amino acid leucine was recorded the highest level in quail eggs (8.95 g / 100 g protein), while lysine amino acid was the highest in chicken eggs (7.47 g / 100 g protein). Tryptophan was the first limiting amino acid in all investigated samples. The results revealed that the protein efficiency ratio (PER) for both quail and chicken eggs was 3.29 and 3.21, respectively. Therefore, the biological value of the quail egg protein was higher than that of the chicken egg protein. So, the current study confirmed the vital and economic importance of quail eggs, and suggested that it is necessary to more studies to identify the health impact of quail eggs consumption.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
39
56
https://jedu.journals.ekb.eg/article_73533_83d169768de3a836ec32eebbafb3cc44.pdf
dx.doi.org/10.21608/jedu.2019.73533
Effect of Fennel and Dill Seeds on Serum Lipid Profiles of Rats Feeding High Fat Diet
Wafaa A
Refaat
specific education minia university
author
Doaa E. El
Nassag
specific education minia university
author
text
article
2019
ara
D ill and fennel seeds are herbal plants cultivated in various regions worldwide; they have many therapeutic effects such as anti-inflammatory, antibacterial, antiviral, anti-hyperlipidemia and antidiabetic. Therefore, this study was conducted to examine the effect of fennel and dill seeds powder on serum lipid profile of rats feeding high fat diet. Forty adult male albino rats weighting (200 ±7g) were divided into eight equal groups of 5 animals each, one was kept as a control (-Ve) group, while the other 7 groups were fed on high fat diet (HFD), group (2) were left as a control (+Ve) fed on HFD only all experiment period (28 days), groups (3,4) fed on HFD+ 2.5% and 5% of dill seeds, respectively, while groups (5,6) fed on HFD+ 2.5% and 5% of fennel seeds, respectively, the last groups (7,8) fed on dill and fennel seeds mix (50/50 w/w) with 2.5% and 5%, respectively. At the end of experiment serum glucose level, liver enzymes activities, kidney functions and lipid profile were examined. The results indicated that the increase of fennel seeds or dill seeds concentration resulted in reduction of serum glucose level and significant (p≤0.05) decreased serum very low-density lipoprotein (VLDL), low density lipoprotein (LDL), triglyceride and cholesterol. Also, the results revealed that fennel seeds have a better effect than dill seeds on high density lipoprotein (HDL) level. Treatment with fennel seeds or dill seeds at different levels caused significant (p≤0.05) decreased uric acid, creatinine and urea levels compared to positive control group. The results also revealed there no significant differences between the groups in albumin level. There was a significant (p≤0.05) decrease in the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of fennel seeds and dill seeds groups compared to positive control group. Therefore, the present study concluded that fennel and dill seeds powder could be used into daily foods and beverages as hypo-lipidemic herbs.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
57
77
https://jedu.journals.ekb.eg/article_73555_01607042c4f8989397693fd44ab9c738.pdf
dx.doi.org/10.21608/jedu.2019.73555
Aflatoxin B1 induces oxidative stress in rats: possible protective effects of onion juice (Allium cepa L.)
Ragaa A
Sadeek
specific education minia university
author
Ghada Mahmoud
Elbassiony
specific education minia university
author
Yousif A
Elhassaneen
specific education minia university
author
text
article
2019
ara
flatoxin belongs to a group of fungal toxins known as mycotoxins. Exposure to dietary aflatoxin B1 (AFB1) is considered to be an important risk factor for the development of hepatocellular carcinoma for both animals and human beings. The mechanism of AFB1 -induced cellular damage has not been fully understood, however previous in vitro studies suggested that AFB1 was capable of inducing oxidative damages through the release of reactive oxygen species (ROS). Onions as one of the important Allium species commonly used in our daily diets are proved recently to have antioxidant properties. Therefore, the present study was conducted to investigate the possible protective effects of onion juice (OJ) in comparison with vitamin C as a standard antioxidant against AFB1 induces oxidative stress in liver tissue of albino rats. Data of the biochemical analysis indicated that AFB1 induced a significant (p≤0.05) increased in plasma oxidants concentration (MDA, 61.73 and123.46%; NO2, 61.90 and 111.69% and NO2/NO3, 66.76 and 107.48%) and significant (p≤0.05) decreased in plasma non-enzymes antioxidant (GSH, -23.78 and - 32.43% and GSSG, - 26.06and -31.69%), plasma antioxidant vitamins (vitamin A, - 30.85 and - 35.82%; vitamin C, - 31.97 and - 37.18% and vitamin E, - 38.79 and - 43.38%) as well as RBC's antioxidant enzymes (GSH-Px, - 23.78 and -32.43%; CAT, - 17.69 and - 21.13% and SOD, -36.91 and - 47.12%) as a percent of normal group in both single and multiple doses, respectively. Injection with OJ induced significant (p≤0.05) improvement in all of these parameters by different rates. The higher amelioration effects were recorded for multiple doses treatment. In conclusion, the present data support the benefits of onion in human population at high risk to AFB1 exposure through alleviating oxidative stress and enhancing the antioxidative defense systems associated.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
79
109
https://jedu.journals.ekb.eg/article_73655_e8c232b644bd73326690c16c41d775cc.pdf
dx.doi.org/10.21608/jedu.2019.73655
Antioxidant Activity of Beetroot Powder on Alloxan Induced Diabetic Rats
Wafaa A
Refaat
Home economic faculty
El monefia university
author
Doaa E
El-Nassag
specific education alex university
author
text
article
2019
ara
iabetes mellitus (DM) is one of the most serious diseases that affect human health; DM is predicted to be the seventh leading cause of death by 2030 in the world. Diabetes particularly Type 2 is characterized by persistent production of reactive oxygen species (ROS) and generation of oxidative stress. Natural antioxidants have shown improving in treatment of diabetes. Therefore, this study was conducted to investigate the antioxidant activity of beetroot powder (BP) in different concentrations on alloxan - induced diabetic rats. Thirty adult male albino rats weighting (160±10) were divided into 5 equal groups of 6 animals each, one was kept as a control -Ve group, while the other 4 groups were treated with alloxan (150 mg/kg body weight) to induce diabetes mellitus. Group (2) were left as a control +Ve (diabetic rats) fed on normal diet at all experiment period (28 days), group 3,4 and 5 diabetic rats treated with 2%, 4% and 8% of beetroot powder, respectively. Liver enzymes activities, lipid profiles, antioxidant enzymes and glucose level in serum were examined. Significant increased in antioxidant enzymes activities of groups treated with beetroot powder in different concentrations. Treatment with BP with different concentration resulted in decreasing the rise of mean serum liver enzymes activities and prevented the rise of mean glucose concentrations in diabetic groups. On conclusion, the present study demonstrated the daily consumption of beetroot powder with meals could be potentially useful in improving hyperglycemia and diabetic complications.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
111
126
https://jedu.journals.ekb.eg/article_73657_fb675ceaf763b947d1155918c5c0f89b.pdf
dx.doi.org/10.21608/jedu.2019.73657
Potential effect of Sesame (Sesamum Indicum) seeds and oil on iron deficiency anemia in rats
Rehab Ibrahim
Tag Al Deen
1Home Economics Dept., Faculty of Specific Education, Zagazig University, Egypt.
author
Rania Shams El deen
Fakher Eldeen
Home Economics Dept., Faculty of Specific Education, Tanta University .Egypt.
author
text
article
2019
ara
S esame is rich in bioactive food components has therapeutic properties on anemia in rats. The present study aimed to evaluate the effect of sesame seeds and its oil on management of anemia, lipid profile and improve antioxidant status in animal. This study was conducted on twenty albino male rats and categorized into 4 groups (5 rats per each). Group (1) kept as normal group (control -ve), while the other three groups were administered a single dose of phenyl hydrazine injection 40 mg/kg/day for two days, then rats categorized into three groups which were group 2 control positive (+ve) (untreated) and groups (3and 4) treated with 15% as a powder of sesame seeds and 5 ml of oil by stomach tube daily for eight weeks, respectively. The obtained results revealed that sesame seed and oil contain highest amount of phenolic compounds and polyunsaturated fatty acids. The biological results showed that significant (p≤0.05) increase in hemoglobin and RBCs were noticed in rats treated with sesame seeds and oil when compared with positive control> Also, significant (p≤0.05) increase in total antioxidants (TA), superoxide dismutase (SOD), were observed in rats treated with Sesame seeds and oil than positive control. The results showed that a decrease significantly (p≤0.05) in serum triglyceride, total cholesterol and LDL-c, VLDL-c levels and a significant (p≤0.05) increase in HDL-c level were spotted in rats treated with sesame seed and oil than positive control. Keywords: Sesame seeds, total phenolic compounds, hemoglobin, antioxidants, nutritional deficiencies. .
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
127
141
https://jedu.journals.ekb.eg/article_73659_50dc0abab7be1a361945e596c045f1c2.pdf
dx.doi.org/10.21608/jedu.2019.73659
Effect of Moringa oleifera on Hemato-Biochemical and Histological Alterations in Rats after Exposure to HighVoltage Electromagnetic Field
Tony S
kasem
minia university
author
text
article
2019
ara
Electromagnetic fields (EMFs) have various chemical effects, including deterioration in large molecules in cells and imbalance in ionic equilibrium. The current study investigated the effect of electromagnetic field generated by high voltage (HV) 5.4 k/v for 2,4h per day with frequency equals 50Hz on body weight, blood indices and some liver enzymes of albino rats after exposing them to the electromagnetic field for 25 days. This work focuses on the therapeutic action of methanolic extract of Moringa oleifera (M. oleifera) leaves at dose (300 mg/kg B.W) against harmful effects induced by electromagnetic field. Results showed that electromagnetic field exposure caused a significant decrease in an organs weight, RBCs, Hb and CAT. While WBCs, AST, ALT, Total Bilirubin, Urea, Creatinine, Uric Acid and MDA levels were significantly increased under electromagnetic field exposure. Treatment with M. oleifera revealed attenuation in these parameters that had been caused in rats exposed to HV. These results were supported by histopathological examination of liver and brain sections
In conclusions, M. oleifera leaves extract afforded significant protection against HV induced liver and other organs injury and therefore may have application in the field of drug development
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
143
166
https://jedu.journals.ekb.eg/article_108792_0d63fd7f3ce84c93ba6d049c060bbe9f.pdf
dx.doi.org/10.21608/jedu.2019.108792
Occurrence of Aflatoxin B1 in wheat grains samples stored in Egyptian homes: seasonal and regional studies
Ahdab A
Elmaadawy
Faculty of Specific Education, Zagazig University
author
text
article
2019
ara
The present study aims to investigate the occurrence of aflatoxin B1, the most important mycotoxins and potent natural carcinogen known, in wheat grains samples stored in Egyptian homes. Wheat (Triticum vulgare L.) grains samples were collected from different villages in two Egyptian Governorates, Sharqia and Minia, during the period (2017-2018) and used immediately for Aflatoxin B1 (AFB1), moisture and fat determination. AFB1 in samples were varied from 0.89 to 3.12 and 1.01 to 3.79 µg.kg-1 in Sharqia and Minia governorates samples, respectively. Also, the moisture and fat contents were varied from 12.67 to 16.02 and 1.28 to 1.93 g.100g-1 (in Sharqia) and 12.79 to 15.79 and 1.42 to 1.94 g.100g-1 (In Minia) Governorates samples, respectively. Samples with the higher AFB1 concentration are the samples of higher moisture and fat content. A percent of 33.33 and 41.66% of the tested wheat grains samples recorded AFB1 concentration more than the maximum permissible limits for human consumption (2 μg/kg AFB1) in Sharqia and Minia Governorates, respectively. When all wheat samples were included in the statistical analysis, there was a positive significant (p≤ 0.05) relationship between moisture content (r2 = 0.6878), fat content (r2 = 0.6373) and AFB1 concentration. These correlations confirm that moisture content is mainly participate for the AFB1 concentration of the tested wheat grain samples while fat content are partially participated. Significant variations in AFB1 were observed amongst the samples tested which clearly indicated seasonality and regional factors affected. In conclusion, consumption of some wheat sampled storage by traditional methods can pose a potential risk of development of various diseases in human as the result of such wheat grains with high levels of AFB1. Also, for the proper storage of wheat grains, environmental factors such as moisture content and temperature must be controlled.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
176
183
https://jedu.journals.ekb.eg/article_108794_7dda6fbe94f85f4dc7f67d6f03318f44.pdf
dx.doi.org/10.21608/jedu.2019.108794
Infestation of wheat flour by flour beetles (Tribolium castaneum) affected in its chemical and toxicological properties and validity for human consumption
Eman B.
Mehram
Faculty of Specific Education, Benha University
author
text
article
2019
ara
Wheat flour represents a significant worldwide food. In many Asian and African countries including Egypt, big quantities of the flour are stored in open shounas and/or shades. Under such conditions, flour is subjected to attack by various biological factors including insects. The tenebrionid beetles such as Tribolium confusum represents an important species of the insect pests of wheat flour. Therefore, the present study aims to investigate the chemical and toxicological properties of wheat flour as affected by flour beetles (Tribolium castaneum) infestation as well as its validity for human consumption. Twenty seven jars, 1 kilogram, of flour (extraction 82%) were used filled with wheat flour 82 % extraction. A100 larvae of Tribolium confusum were put into each jar and 15 jars, not infested, were kept as control. The samples were kept for the trial duration (2, 4, 6, and 8 weeks) at 25 0C and 60% of relative humidity. At the end of this period, all samples were sieved to recover the insects and then analyzed. The obtained data indicated that, in the end of infestation periods (8 weeks), chemical alterations include a significant (p≤0.01) increasing in flour fat characteristics such total acidity and peroxide values which recorded 49.60 and 94.08% compared to 3.13 and 1.75% for the uninfested/control samples, respectively. The opposite direction was recorded for the iodine number. On the other side, infestation of wheat flour with insects leads to increase in quinones and malonaldehyde content, which represent some of the most extensively studied toxic, mutagenic and carcinogenic compounds, that significant (p≤0.01) increased by the rate of 264.71 and 26.53% compared to 1.02 and 2.04% for the uninfested/control samples, respectively. The same trend was observed with uric acid, as excretion of arthropods and main reason for the gout disease in human; and ergosterol, a steroid involved in some biochemical process in insects and mould metabolite. In conclusion, all of these data means lipids of wheat flour become rancid as a consequence of oxidation and oxidative rancidity initiated by infestation with insects after 6 - 8 weeks of infestation. Also, the presence of significant amount of the determined toxic compounds in infested wheat flour with beetles that introduced by substantial quantities into the bakery products may be represented a great concern/hazard for the community health
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
185
201
https://jedu.journals.ekb.eg/article_108799_c9814e1becae814f7423ccd93b4025d2.pdf
dx.doi.org/10.21608/jedu.2019.108799
Effect of coconut fruits on some biological changes in obese rats induced
Omar Ahmed
Emam
Faculty of Specific Education, Benha University
author
text
article
2019
ara
The aim targets of this works is study the effect of coconut kernel powder with different ratio 5,10 and 15% on chemical, biological changes of rats induced obesity. Chemical composition, phenols, flavonoids, DPPH radical assay and fatty acids of coconut powder were studied. In addition, biological parameters were studied. Results showed that it could be concluded that coconut kernel powder is considered as a good source of oil, crude fiber, ash content, protein carbohydrates, total calories and has an antioxidant properties. Also it is a rich source of medium-chain triglyceride, mainly lauric acid, with approximately have the amount of fatty acids. Total saturated fatty acids represent 94.59%. Biological evaluation revealed that obesity rats fed on diet supplemented by coconut powder showed significant decrease (P ≤ 0.05) of body weight, total lipids, cholesterol, triglyceride, LDLC and VLDLC. In addition, diet containing coconut powder significant decreased (P≤ 0.05) in liver enzymes (AST, ALT and LAP) and kidney functions (urea, uric acid and creatinine) of obesity rats. Moreover, increased both serum protein and albumin and lowering blood glucose. Were observed.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
203
224
https://jedu.journals.ekb.eg/article_108804_58690b97d1c05d95036f021c03d87fa0.pdf
dx.doi.org/10.21608/jedu.2019.108804
Effect of pine fruits on some biological changes in hypercholesterolemia rats induced
Mashael Mobard Ahmed
El-Fadly
Faculty of Specific Education, Benha University
author
text
article
2019
ara
This study aimed to determine chemical composition, antioxidant contents, fatty acids of pine nut fruits and also, the effect of pine powder with different ratio (3, 6 and 9%) on biochemical changes of hypercholesterolemic rats. Biological evaluation of growth performance, Lipid profile, serum protein, blood sugars, liver and kidney functions were also studied. The obtained results indicated that pine nut fruits are considered as a good source of oils, crude fibers, ash, protein, soluble carbohydrates, total energy polyphenols and flavonoids. Besides, it is a rich source of unsaturated fatty acids mainly, linoleic acid (C18:2) which represent more than half amount of total fatty acids. Biological evaluations showed that pine nut was significantly decreased (P ≤ 0.05) of body weight, total lipids, triglycerides, LDL, HDL, VLDL cholesterol of serum hypercholesterolemic rats as compared with positive group of rats Also, it caused significant decrease (P ≤ 0.05) in liver enzyme (AST, ALT and ALP) and kidney parameters (urea, uric acid and creatinine, i.e. improved liver and kidney functions as compared with positive control group. Meanwhile, both total protein and albumin were increased.
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
225
243
https://jedu.journals.ekb.eg/article_108809_f81da42413527f7f42b0107bc5c1622b.pdf
dx.doi.org/10.21608/jedu.2019.108809
Studying Protective Effect of Ethanolic Extract of Artichoke (Cynara scolymus) Leaves and Vitamin E against Oxidative Stress Induced in Rats
Neveen S.
Ismail
Faculty of Home Economics, Helwan University
author
text
article
2019
ara
The present study was conduct to evaluate the protective effect of Artichoke leaves extract (ALE) and vitamin E administration against oxidative stress induced by antitumor drug cyclophosphamide (CP) in rats. Forty five male rats were randomized into 5 equal groups. Group (1) was normal rats (negative control), while the other four groups were intraperitoneally injected by a single daily dose of CP (50 mg/kg BW) for 3 days to induce oxidative stress. Group (2) was used as positive control (intoxicated) and groups (3), (4) and (5) received orally daily doses of ALE (400 mg/kg/BW); vitamin E (100 mg/kg/BW) and both ALE and vitamin E for six weeks, respectively. Blood samples were collected for separation of the serum which used for biochemical analyses. Halve of livers of the sacrificed rats was used for preparing liver homogenates for biochemical analyses. The other halve was used for histopathological examination. The results showed that oral administration of ALE increased body weight gain in CP- administered rats. ALE decreased the high serum levels of liver enzymes; normalized serum levels of total protein, total bilirubin, urea, creatinine, total cholesterol, triglycerides, malondialdehyde (MDA) and reduced glutathione (GSH). In hepatic tissues, there were a significant decrease in MDA and increases in GSH levels and activities of antioxidant enzymes (SOD, GPx and CAT). These biochemical alterations were accompanied with mitigation of histopathological lesions (fatty degeneration and necrosis) seen in the liver of CP-intoxicated rats. Concurrent administration of ALE and vitamin E exhibited the best effects when compared to their administration alone. In conclusion, concomitant administration of ALE and vitamin E has hepatoprotective, nephroprotective, hypolipidemic and antioxidant activities in CP-intoxicated rats. The study recommends that intake of edible parts of artichoke leaves in food or as an herbal tea with vitamin E as a food supplement may be beneficial for patients suffering from liver and kidney diseases due to oxidative stress. Isolation of bioactive constituents of artichoke leaves is necessary also to search for safe natural antioxidant agents to be developed for therapy of liver and kidney diseases
مجلة البحوث في مجالات التربية النوعية
جامعة المنيا، کلية التربية النوعية
1687-3424
5
v.
العدد 22 اقتصاد (تغذیة)
no.
2019
245
262
https://jedu.journals.ekb.eg/article_108813_0c14c2165123d68eef9c06e24ede49b9.pdf
dx.doi.org/10.21608/jedu.2019.108813